Endocrine Abstracts

Background and Objectives: With menopausal transition, there is decline in estrogen concentration with potential vasomotor, physical, psychosocial, and sexual health consequences. The loss of muscle mass, strength, and function, known as sarcopenia is common in postmenopausal women. The primary objective of this study is to assess the menopausal symptoms in postmenopausal women and its association with sarcopenia.Methods: This study was conducted from Ja...

BackgroundDyslipidemia is relevant association of hypothyroidism and consists of raised levels of total cholesterol, apolipoprotein B, triglycerides, low density lipoprotein (LDL) cholesterol, and reduced levels of high density lipoprotein (HDL) cholesterol.Thyroid hormones also have a role in modulating glucose metabolism and insulin resistance. The aim of study was to assess glycemic status, Homeostasis model assessment–estimated Insulin Resistanc...

Androgen excess in post-menopausal women usually results from ovarian or adrenal pathology. Identifying pathology is significant as many ovarian tumors can be malignant in nature. We report a case of granulosa cell tumor which presented with virilizing signs. A 66-year-old postmenopausal lady presented with temporal hair loss and weight gain. She had to drop out of her church choir as she had a change in her voice. She was concerned about her facial hair growth which was signi...

Background: In India, physicians recognise the need for communication skills training (CST) so as to improve patients’ physical and mental wellbeing. Yet, there is a lack of culturally informed and evidence-based training programs in the current medical curriculum. In our pilot study, we explored the cultural suitability of the Relationship: Establishment, Development and Engagement (REDE) model for CST for Indian physicians. The REDE model proposes three ways (i.e., esta...

Women diagnosed with polycystic ovarian syndrome (PCOS) experience several physiological (weight gain, hirsutism, acne) and psychological challenges (emotional distress, anxiety, shame). This is particularly apparent in India where PCOS intersects with gender and patriarchal notions of womanhood (interfering with one’s marital prospects, compromising one’s ability to procreate). A young woman’s first source of support, therefore, is usually their mother. In Indi...

Background: Osteogenesis imperfecta is a systemic connective tissue disorder characterized by low bone mass and bone fragility leading to low-trauma fractures or fractures in atypical locations. Extraskeletal manifestations may include dental anomalies, blue-gray sclera, hearing loss, joint hypermobility, muscle weakness, cardiovascular and pulmonary complications.Case presentation: A 7year old boy presented with a history of fracture right femur 1 month...

Background: Hirsutism is a common and disturbing complaint among women attending endocrine clinics. It is caused by androgen excess and when severe, might progress to virilization. Virilizing adrenal tumors are a rare cause of hirsutism.Case presentation: A 14 year old girl presented with primary amenorrhea, poor breast development (Tanner stage B1), hirsutism (Ferriman-gallwey score, FGS of 12/36) clitoromegaly (clitoral index >200 mm2). ...

Background: People with chronic metabolic conditions such as type 2 diabetes (T2D) encounter challenges with self-management regimens to improve their glycemic control, weight and as well as to reduce complications associated with diabetes. Optimal management of T2D requires regular monitoring by physician, access to multidisciplinary care and achieving target HbA1c without hypoglycemia. Digital therapeutics (DTx) provide highly accessible, cost-effective, evidence-based solut...

Background and aim: Early glycemic control and weight reduction in diabetes has been associated with prevention of progression of β-cell dysfunction and reduction in diabetes-related complications. Digital therapeutics (DTx) platforms can provide evidence-based therapeutic interventions to improve glycemic control using sustainable behavior change. This study aims at assessing the real-world effectiveness of the Fitterfly Diabetes program in improving glycemic control and...

Introduction: National Institute of Health and Care Excellence (NICE) recommends screening for emotional wellbeing as part of consultations for polycystic ovary syndrome (PCOS).Aim: We evaluated several dimensions of emotional wellbeing in people attending PCOS consultation in the UK and India.Methods: All people attending reproductive endocrine clinic for PCOS at three centres: Queen Elizabeth Hospital Birmingham, UK; Apollo Hospi...